Description

(S)-Amlodipine CAS NO 103129-82-4 is the single enantiomer form of the widely prescribed dihydropyridine calcium channel blocker, amlodipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure pharmaceuticals, offering superior specificity and reduced side-effect profiles compared to racemic mixtures. It is an essential building block for advanced pharmaceutical manufacturers and research institutions focused on cardiovascular drug discovery, process development, and the production of novel therapeutic agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral intermediate in the manufacture of enantiopure (S)-amlodipine besylate, the active component in antihypertensive and antianginal medications.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the pharmacokinetics, pharmacodynamics, and efficacy of the (S)-enantiomer.
• Process Chemistry & Optimization: Serves as a reference standard and starting material for developing and scaling up efficient, asymmetric synthetic routes.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for HPLC, LC-MS, and chiral assay method development and validation.
• Formulation Development: Used in the development of novel drug delivery systems and dosage forms for targeted cardiovascular therapy.
• Regulatory Submissions: Provides the necessary quality and characterization data for drug master files (DMFs) and regulatory dossiers (e.g., for FDA, EMA).

Basic Information

Product Name	(S)-Amlodipine
CAS No.	103129-82-4
Molecular Formula	C20H25ClN2O5
Molecular Weight	408.88 g/mol
Synonyms	(S)-Amlodipine; (S)-Amlodipine Base; (-)-Amlodipine; Levamlodipine; (S)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; (S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester; Amlodipine (S)-enantiomer
EINECS	Contact for details

Quality Control

Our (S)-Amlodipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and enantiomeric excess. We provide full traceability and support regulatory requirements with comprehensive documentation. Certificates of Analysis (COA) detailing HPLC purity, chiral purity, residual solvents, and other critical parameters are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.