Description

(+/-)-Verapamil Hydrochloride CAS NO 152-11-4 is a calcium channel blocker belonging to the phenylalkylamine class, widely recognized for its pharmacological activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development. It is essential for manufacturers and researchers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity active pharmaceutical ingredients (APIs) and analytical standards.

Application

• Pharmaceutical API Synthesis: A key intermediate in the production of verapamil hydrochloride, a medication used to treat hypertension, angina, and certain cardiac arrhythmias.
• Biochemical Research: Used as a reference standard in studies investigating calcium channel physiology, cardiovascular pharmacology, and cellular signaling pathways.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and assay development in pharmaceutical laboratories.
• Process Development: Employed in the development and optimization of synthetic routes for calcium channel blocker drugs within R&D and pilot-scale operations.
• Metabolite Studies: Utilized in the synthesis and identification of verapamil metabolites for pharmacokinetic and toxicological research.

Basic Information

Product Name	(+/-)-Verapamil Hydrochloride
CAS No.	152-11-4
Molecular Formula	C27H38N2O4 • HCl
Molecular Weight	491.07 g/mol
Synonyms	Verapamil HCl; (±)-Verapamil Hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride; Iproveratril Hydrochloride; Cordilox; Isoptin; Anpec; Calan; CP-16533-1
EINECS	205-800-7

Quality Control

Our (+/-)-Verapamil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.