Description

Lomerizine CAS NO 101477-55-8 is a selective calcium channel blocker belonging to the diphenylpiperazine class. This compound is of significant interest in pharmaceutical research and development due to its neuroprotective properties and potential to modulate cerebral blood flow. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of treatments for cerebrovascular disorders and migraine prophylaxis.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or precursor in the synthesis of neuroprotective medications.
• Neurological Research: Used in preclinical and clinical studies investigating treatments for cerebral ischemia, stroke, and other cerebrovascular conditions.
• Migraine Prophylaxis Development: Applied in research focused on developing preventive therapies for migraine and related headaches.
• Vasodilator Studies: Employed in pharmacological research to study its effects on cerebral and peripheral blood vessel dilation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic & Contract Research: Utilized by universities and CROs (Contract Research Organizations) for fundamental pharmacological and toxicological studies.

Basic Information

Product Name	Lomerizine
CAS No.	101477-55-8
Molecular Formula	C₂₈H₃₄F₂N₂O₂
Molecular Weight	468.58 g/mol
Synonyms	Lomerizine; KB-2796; 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine; KB2796; 1-[(4-Fluorophenyl)(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
EINECS	Contact for details

Quality Control

Our Lomerizine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets high-grade standards suitable for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.