Description

(R)-Amlodipine is the single enantiomer of the widely prescribed calcium channel blocker amlodipine, specifically targeting the (R)-configuration. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective pharmacology and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery, enantiomeric separation studies, and the development of stereochemically pure therapeutics.

Application

• Key chiral building block for the research and synthesis of novel calcium channel blockers.
• Reference standard for analytical method development and validation in enantiomeric purity testing.
• Critical material for pharmacological studies investigating the stereoselective effects of amlodipine enantiomers.
• Intermediate in the development and production of single-enantiomer pharmaceutical products.
• Used in academic and industrial research focused on cardiovascular disease mechanisms and treatments.
• Essential for quality control laboratories to calibrate instruments for chiral separation techniques like HPLC and CE.

Basic Information

Product Name	(R)-Amlodipine
CAS No.	103129-81-3
Molecular Formula	C20H25ClN2O5
Molecular Weight	408.88 g/mol
Synonyms	(R)-Amlodipine; (R)-Amlodipine Besylate; (R)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; (R)-Norvasc; Amlodipine (R)-enantiomer; (R)-Amlodipine Free Base; (R)-Amlodipine Maleate
EINECS	Contact for details

Quality Control

Our (R)-Amlodipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, enantiomeric excess (ee) determination, and identification by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.