Description

Niguldipine is a potent and selective calcium channel blocker of the dihydropyridine class, recognized for its high affinity for L-type calcium channels. This compound is a critical research chemical used extensively in pharmacological studies to investigate cardiovascular physiology and calcium signaling pathways. It serves as an essential tool for researchers and pharmaceutical developers in the fields of cardiology, neuropharmacology, and drug discovery.

Application

• Pharmacological Research: A key reference standard and active pharmaceutical ingredient (API) in studies of calcium channel modulation and cardiovascular function.
• Drug Discovery & Development: Used as a lead compound or biochemical tool in the synthesis and screening of novel therapeutic agents targeting hypertension and angina.
• Biochemical Assays: Employed in in vitro and in vivo assays to study vasodilation, smooth muscle contraction, and intracellular calcium dynamics.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in molecular pharmacology and signal transduction.
• Reference Standard: Serves as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Niguldipine
CAS No.	102993-22-6
Molecular Formula	C28H30N2O6
Molecular Weight	490.55 g/mol
Synonyms	Niguldipine; BAY a 7168; BAY a-7168; BAY a7168; (RS)-Niguldipine; (±)-Niguldipine; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester; 5-O-Methyl 3-O-[2-(N-benzyl-N-methylamino)ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our Niguldipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.