Description

Lercanidipine is a potent and highly selective dihydropyridine calcium channel blocker. This active pharmaceutical ingredient (API) is critical for the formulation of antihypertensive medications, offering a long duration of action and a favorable side effect profile. It is essential for pharmaceutical manufacturers and research institutions developing treatments for cardiovascular diseases, particularly hypertension. The compound is supplied under the identifier CAS NO 100427-26-7.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive drug formulations.
• Finished Dosage Forms: Manufacture of tablets and other solid oral dosage forms for the treatment of hypertension.
• Cardiovascular Research: A key reference standard and tool in pharmacological studies of calcium channel modulation.
• Generic Drug Production: Sourcing for the development and production of generic lercanidipine hydrochloride medications.
• Analytical Standard: Used as a high-purity standard in quality control (QC) and analytical method development (e.g., HPLC, LC-MS).
• Preclinical & Clinical Trials: Serves as the core material for investigational new drug (IND) applications and clinical trial material (CTM) manufacturing.

Basic Information

Product Name	Lercanidipine
CAS No.	100427-26-7
Molecular Formula	C36H41N3O6
Molecular Weight	611.73 g/mol
Synonyms	Lercanidipine Hydrochloride; (2S)-1,1-Dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate; Lercanidipine HCl; Lercanidipinum; Lercanidipino; Lercanidipin; Rec 15/2375; Masnidipine; Zanedip
EINECS	Contact for details

Quality Control

Our Lercanidipine is manufactured under strict quality management systems. It is tested to meet stringent specifications for pharmaceutical-grade active ingredients, with a focus on purity, identity, and impurity profiles. Certificates of Analysis (COA) are provided with each batch, detailing results from comprehensive analytical methods including HPLC, IR, and residual solvent analysis. We support compliance with major pharmacopeial standards (e.g., USP, EP) and ICH Q7 GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.