Description

Barnidipine Hydrochloride is a high-purity active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. This compound is critical for the research and development of antihypertensive medications, offering a targeted mechanism of action. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in cardiovascular drug discovery and formulation.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of antihypertensive and antianginal medications.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and quality control testing.
• Biochemical Research: A key tool for studying calcium channel physiology, vascular smooth muscle contraction, and related cardiovascular pathways.
• Preclinical Studies: Employed in pharmacological and toxicological evaluations during the drug development pipeline.
• Generic Drug Manufacturing: Serves as the core component for producing generic versions of calcium channel blocker therapies.

Basic Information

Product Name	Barnidipine Hydrochloride
CAS No.	101979-04-8
Molecular Formula	C27H29N3O6·HCl
Molecular Weight	528.00 g/mol
Synonyms	Barnidipine HCl; Mepirodipine Hydrochloride; YM-09730-5; (±)-Barnidipine Hydrochloride; (R*,S*)-1-Benzyl-3-pyrrolidinyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Hydrochloride; 3-(1-Benzyl-3-pyrrolidinyl) 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
EINECS	Contact for details

Quality Control

Our Barnidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.