Description

(±)-Davapamil CAS NO 102268-75-7 is a synthetic calcium channel blocker belonging to the verapamil analogue class, widely utilized in pharmacological research and development. Its primary value lies in its role as a key reference standard and active pharmaceutical ingredient (API) intermediate for investigating cardiovascular therapeutics and cellular calcium signaling pathways. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on drug discovery, metabolic studies, and analytical method validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control (QC) and analytical method development in API manufacturing.
• Cardiovascular Research: Used as a pharmacological tool to study L-type calcium channel inhibition and its effects on heart muscle and vascular smooth muscle.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical building block in the synthetic pathway for producing verapamil-type calcium antagonist drugs.
• Metabolic and Pharmacokinetic Studies: Employed in in vitro and in vivo studies to understand drug absorption, distribution, metabolism, and excretion (ADME).
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) assays to identify and characterize new calcium channel modulators.

Basic Information

Product Name	(±)-Davapamil
CAS No.	102268-75-7
Molecular Formula	C27H38N2O4
Molecular Weight	454.60 g/mol
Synonyms	Davapamil (racemic); (±)-D-888; D-888 (racemate); 2-Isopropyl-5-(methylamino)-2-phenylvaleronitrile; 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-isopropylvaleronitrile; Racemic Davapamil; D888; Gallopamil analogue
EINECS	Contact for details

Quality Control

Our (±)-Davapamil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.