Description

3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl 1-(Phenylmethyl)-3-Pyrrolidinyl Ester, Monohydrochloride, (R*,R*)-(+-)- is a high-purity, complex organic salt with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key chiral building block for the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in cardiovascular and neurological research. This product is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers requiring a reliable supply of high-quality, structurally complex intermediates for new drug development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly calcium channel blockers and other cardiovascular drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry: Serves as a critical starting material or intermediate in the optimization and scale-up of API manufacturing processes under GMP conditions.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined (R*,R*)-(+-) configuration for constructing molecules with specific chiral centers.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl 1-(Phenylmethyl)-3-Pyrrolidinyl Ester, Monohydrochloride, (R*,R*)-(+-)-
CAS No.	101930-04-5
Molecular Formula	C27H29N3O6 • HCl
Molecular Weight	528.00 g/mol (for free base: 491.54 g/mol)
Synonyms	Methyl 1-Benzyl-3-pyrrolidinyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Hydrochloride; (±)-Methyl 1-Benzyl-3-pyrrolidinyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Monohydrochloride; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 1-(Phenylmethyl)-3-pyrrolidinyl Ester Hydrochloride; Nifedipine Impurity; Nifedipine Related Compound; Nifedipine Analog; Calcium Channel Blocker Intermediate; Benzylpyrrolidine Ester of Dihydropyridine Hydrochloride
EINECS	Contact for details

Quality Control

Our 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl 1-(Phenylmethyl)-3-Pyrrolidinyl Ester, Monohydrochloride, (R*,R*)-(+-)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment. We can support development with analytical methods and specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (as specified isomer)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.