Description

Lomerizine Hydrochloride is a high-purity pharmaceutical intermediate and research chemical, identified by CAS NO 101477-54-7. It is a calcium channel blocker primarily valued for its neuroprotective properties and its role in the development of treatments for cerebrovascular disorders. This compound is essential for researchers in neuroscience and for manufacturers in the pharmaceutical industry developing therapies for migraines and cerebral ischemia. Its consistent quality and reliable supply are critical for ensuring the integrity of preclinical studies and production processes.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: A key synthetic precursor in the production of finished drug formulations targeting cerebrovascular conditions.
• Neuroscience Research: Used in preclinical studies to investigate mechanisms of calcium channel blockade and neuroprotection in models of stroke and brain injury.
• Migraine Therapy Development: Employed in R&D for formulating and testing new therapeutic agents aimed at preventing and treating migraines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Assays: Utilized as a tool compound in vitro to study vascular smooth muscle relaxation and cerebral blood flow regulation.

Basic Information

Product Name	Lomerizine Hydrochloride
CAS No.	101477-54-7
Molecular Formula	C₂₈H₃₄F₂N₂O₃·HCl
Molecular Weight	521.04 g/mol
Synonyms	Lomerizine HCl; KB-2796; 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine Hydrochloride; (1E,4E)-1,5-Bis(4-fluorophenyl)penta-1,4-dien-3-one; 1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one Hydrochloride
EINECS	Contact for details

Quality Control

Our Lomerizine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) documenting all test results are provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.