Description

Fosinoprilat CAS NO 95399-71-6 is the active diacid metabolite of the prodrug Fosinopril, representing a critical angiotensin-converting enzyme (ACE) inhibitor. This compound is of paramount importance in pharmaceutical research and development for studying the mechanism of action, pharmacokinetics, and metabolite profiling of antihypertensive drugs. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in cardiovascular drug development, bioequivalence studies, and the synthesis of reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of Fosinopril and its metabolites in drug substances and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the research-scale synthesis and process development of Fosinopril sodium and related prodrug formulations.
• Metabolite Profiling & Pharmacokinetics: Essential for in-vitro and in-vivo studies to understand the metabolic pathway, distribution, and elimination of ACE inhibitor drugs.
• Analytical Method Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other chromatographic assays in quality control laboratories.
• Biochemical Research: Used as a tool compound to investigate the inhibition mechanism of ACE and its role in the renin-angiotensin system (RAS).
• Impurity Standard: Acts as a specified impurity standard for monitoring and controlling the quality of Fosinopril API according to ICH guidelines.

Basic Information

Item	Detail
Product Name	Fosinoprilat
CAS No.	95399-71-6
Molecular Formula	C30H45NO7P
Molecular Weight	562.66 g/mol
Synonyms	Fosinoprilat; Fosinopril Diacid; (4S)-4-Cyclohexyl-1-[[(R)-[[(1S)-1-carboxy-3-phenylpropyl]amino](phenylphosphinyl)acetyl]-L-proline; SQ 27,519; SQ-27519; SQ27519; Fosinopril Acid; Fosinoprilate; L-Proline, 4-cyclohexyl-1-[[(R)-[[(1S)-1-carboxy-3-phenylpropyl]amino]hydroxyphenylphosphinyl]acetyl]-
EINECS	Contact for details

Quality Control

Our Fosinoprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results against predefined specifications is provided with every shipment. We support compliance with ICH Q3A, Q3B guidelines and can supply material suitable for use as a pharmaceutical reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.