Description

Perindoprilat is the active metabolite of the widely prescribed antihypertensive drug Perindopril. This high-purity pharmaceutical intermediate is critical for research and development in cardiovascular pharmacology. It is primarily utilized by pharmaceutical manufacturers and research institutions for analytical reference standards, metabolic studies, and the development of new ACE inhibitor formulations. Our supply ensures the stringent quality and consistency required for advanced pharmaceutical applications.

Application

• Pharmaceutical Reference Standard: Serves as a primary chemical reference material (CRM) for quality control and assay development of Perindopril and its formulations.
• Metabolite Research: Essential for pharmacokinetic and pharmacodynamic studies to understand the metabolism and efficacy of Perindopril in biological systems.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a key intermediate or starting material in the synthesis of Perindopril and related compounds.
• Analytical Method Development: Employed in HPLC, LC-MS, and other chromatographic methods for the identification and quantification of Perindopril and its metabolites.
• Biochemical Research: Used in vitro studies to investigate the mechanism of action of angiotensin-converting enzyme (ACE) inhibition.
• Impurity Profiling: Critical for identifying and characterizing related substances and degradation products in Perindopril drug substances and products.

Basic Information

Product Name	Perindoprilat
CAS No.	95153-31-4
Molecular Formula	C19H32N2O5
Molecular Weight	368.47 g/mol
Synonyms	(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic acid; Perindopril Diacid; S-9780; Perindoprilat Anhydrous; Aceon Metabolite; Coversyl Metabolite; (S,S,S)-Perindoprilat
EINECS	Contact for details

Quality Control

Our Perindoprilat is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against relevant in-house or pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.