Description

Spirapril Hydrochloride is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and heart failure. Its primary value lies in its high selectivity and efficacy, making it a critical active pharmaceutical ingredient (API) for cardiovascular medications. This compound is essential for pharmaceutical manufacturers and research institutions developing antihypertensive and cardioprotective drug formulations. Consistent quality and reliable supply are paramount for ensuring the safety and effectiveness of the final medicinal products.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for managing hypertension (high blood pressure).
• Cardiovascular Drug Formulations: Incorporated into tablets, capsules, and other solid oral dosage forms designed for chronic cardiovascular therapy.
• Heart Failure Management: Used in drug products aimed at improving survival and symptoms in patients with congestive heart failure.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in the R&D of new ACE inhibitor drugs and combination therapies.
• Clinical Trial Material: Supplied as a high-purity compound for use in preclinical and clinical studies.
• Generic Drug Manufacturing: A vital component for companies producing bioequivalent generic versions of branded spirapril medications.

Basic Information

Product Name	Spirapril Hydrochloride
CAS No.	94841-17-5
Molecular Formula	C22H30N2O5S2 • HCl
Molecular Weight	503.08 g/mol
Synonyms	Spirapril HCl; (8S)-7-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid hydrochloride; SCH 33844; Renormax; Sandopril; 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our Spirapril Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profile, and residual solvent analysis. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with agreed specifications. We support compliance with major pharmacopoeial standards (e.g., USP, EP) and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.