Description

(R)-Devapamil CAS NO 93468-88-3 is the single enantiomer form of the calcium channel blocker devapamil, characterized by its specific (R)-configuration. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective drug action and metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced cardiovascular drug discovery, chiral synthesis, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the research and synthesis of novel calcium channel antagonists.
• Stereochemical Studies: Used as a reference standard in pharmacological research to investigate the distinct biological activity of the (R)-enantiomer compared to its (S)-counterpart or the racemic mixture.
• Analytical Standard: Employed in method development and validation for chiral separation techniques, such as chiral HPLC or SFC, to quantify enantiomeric purity.
• Metabolism and Pharmacokinetics Research: A vital tool for studying the enantiomer-specific ADME (Absorption, Distribution, Metabolism, and Excretion) properties in preclinical models.
• Academic Research: Used in university and institutional labs for teaching and advanced studies in medicinal chemistry and pharmacology.

Basic Information

Product Name	(R)-Devapamil
CAS No.	93468-88-3
Molecular Formula	C26H38N2O4
Molecular Weight	442.59 g/mol
Synonyms	(R)-(-)-Devapamil; (R)-Devapamil; Dexverapamil (related enantiomer); (2R)-2-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-N-methylpentanenitrile; (R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenecetonitrile; (R)-Enantiomer of Devapamil; R-Devapamil
EINECS	Contact for details

Quality Control

Our (R)-Devapamil is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay by HPLC, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment to guarantee traceability and consistency for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.