Description

Oxolan-2-Ylmethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate is a specialized dihydropyridine derivative, a class of compounds renowned for their significant biological and chemical activity. This high-purity intermediate is critical for research and development in advanced pharmaceutical synthesis, particularly in the creation of novel calcium channel modulators. It serves as a key building block for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the research and synthesis of new drug candidates, especially those targeting cardiovascular and neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Calcium Channel Blocker Analog Synthesis: Serves as a core structure for developing novel analogs of nifedipine-like compounds for potential therapeutic applications.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, high-value molecules in research laboratories.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection products.
• Academic & Institutional Research: Used in universities and research institutes for studying heterocyclic chemistry and reaction mechanisms.

Basic Information

Product Name	Oxolan-2-Ylmethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
CAS No.	92565-17-8
Molecular Formula	C22H24N2O7
Molecular Weight	428.44 g/mol
Synonyms	4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(tetrahydrofuran-2-yl)methyl 5-methyl ester; Methyl (oxolan-2-yl)methyl 4-(3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-[(Tetrahydrofuran-2-yl)methyl] 5-methyl 4-(3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(tetrahydrofurfuryl) 5-methyl ester; Tetrahydrofurfuryl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; 3-(Tetrahydrofurfuryl) 5-methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; DHP derivative with 3-nitrophenyl and tetrahydrofurfuryl ester groups.
EINECS	Contact for details

Quality Control

Our Oxolan-2-Ylmethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.