Description

Benidipine Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is a critical component in the research and development of cardiovascular therapeutics, specifically for hypertension and angina. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on cardiovascular drug discovery and production. The product is supplied under stringent quality control to ensure batch-to-batch consistency and reliability for demanding applications.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of antihypertensive and antianginal medications.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical labs.
• Biochemical Research: Used in pharmacological studies to investigate calcium channel blockade mechanisms and cardiovascular physiology.
• Preclinical & Clinical Development: A key starting material in the development and scale-up of new drug formulations and delivery systems.
• Generic Drug Manufacturing: Essential for companies producing generic versions of benidipine-based medications.
• Academic Research: Utilized in university and institutional research projects exploring cardiovascular disease models and novel therapeutic pathways.

Basic Information

Product Name	Benidipine Hydrochloride
CAS No.	91599-74-5
Molecular Formula	C28H31N3O6·HCl
Molecular Weight	542.02 g/mol
Synonyms	(±)-Benidipine Hydrochloride; KW-3049; Coniel; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 1-benzyl-3-piperidinyl methyl 2-methylethyl ester hydrochloride; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1-benzyl-3-piperidinyl methyl isopropyl ester hydrochloride; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(N-benzyl-N-methylamino)propyl methyl isopropyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Benidipine Hydrochloride is manufactured and tested under a quality management system. Each batch is subjected to rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay, purity, and impurity profiles. We can support compliance requirements for cGMP, ICH Q7, and other relevant pharmaceutical guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.