Description

Quinapril CAS NO 90243-99-5 is a potent, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor widely recognized for its therapeutic applications. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular medications, particularly antihypertensive drugs.

Application

• Primary Pharmaceutical Ingredient: As the core active component in the manufacture of quinapril hydrochloride tablets and other solid oral dosage forms for the treatment of hypertension and heart failure.
• Cardiovascular Research: Used as a reference standard and key material in preclinical and clinical research studies focusing on ACE inhibition mechanisms and cardiovascular disease models.
• Generic Drug Production: Serves as a critical starting material for companies developing and producing bioequivalent generic versions of branded quinapril medications.
• Analytical Standard: Employed in quality control laboratories as a high-purity standard for HPLC, UV, and other chromatographic assays to quantify quinapril in drug substances and products.
• Formulation Development: Utilized in R&D departments for developing new drug delivery systems, stability studies, and compatibility testing with various excipients.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial-scale production of finished dosage forms under cGMP guidelines.

Basic Information

Product Name	Quinapril
CAS No.	90243-99-5
Molecular Formula	C25H30N2O5
Molecular Weight	438.52 g/mol
Synonyms	Quinapril Base; (3S)-2-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; CI-906; Accupril (Brand Name, as HCl salt); Quinaprilat Precursor; ACE Inhibitor Quinapril
EINECS	Contact for details

Quality Control

Our Quinapril is manufactured and tested under strict quality management systems to meet the rigorous standards of the global pharmaceutical industry. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant pharmacopeial monographs (such as USP/EP) and support our clients' needs for regulatory filings with consistent, high-quality material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.