Description

Cilazaprilat is the active diacid metabolite of the prodrug Cilazapril, a well-established angiotensin-converting enzyme (ACE) inhibitor. This compound is a critical pharmaceutical intermediate and reference standard essential for research, quality control, and the development of cardiovascular therapeutics. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and analytical testing facilities engaged in the synthesis and validation of antihypertensive and heart failure medications.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as the direct active moiety in the production pathway for ACE inhibitor drugs.
• Biochemical Research: Used as a potent tool to study the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation.
• Analytical Reference Standard: Employed in High-Performance Liquid Chromatography (HPLC) and other analytical methods for the quality control and assay of Cilazapril and related pharmaceutical formulations.
• Metabolite Studies: Crucial for pharmacokinetic and pharmacodynamic research to understand the in vivo conversion and activity profile of the parent drug.
• Process Development & Validation: Used in the development and scaling of synthetic routes for cardiovascular APIs under GMP conditions.

Basic Information

Item	Detail
Product Name	Cilazaprilat
CAS No.	90139-06-3
Molecular Formula	C22H31N3O5
Molecular Weight	417.50 g/mol
Synonyms	(S)-1-[(S)-6-Oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidin-4-yl]-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]proline; Cilazapril Diacid; Cilazaprilat Anhydrous; (S)-1-[(S)-6-Oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidin-4-yl]-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]pyrrolidine-2-carboxylic acid; Ro 31-3113; UNII-4M862E2GNA
EINECS	Contact for details

Quality Control

Our Cilazaprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.