Description

Zabiciprilat CAS NO 90103-92-7 is a high-purity pharmaceutical intermediate and active metabolite of the ACE inhibitor Zabicipril. This compound is critical for research and development in cardiovascular pharmacology, serving as a key reference standard and building block. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, bioequivalence testing, and the synthesis of next-generation antihypertensive agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of Zabicipril and its metabolites in biological matrices via HPLC or LC-MS/MS.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic precursor in the manufacturing process of Zabicipril and related cardiovascular drugs.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the pharmacokinetics, pharmacodynamics, and metabolic pathways of ACE inhibitor drugs.
• Analytical Method Development: Employed to develop and validate robust analytical methods for quality control and regulatory submissions.
• Impurity Profiling: Used to identify, characterize, and quantify process-related impurities and degradation products in drug substances.

Basic Information

Product Name	Zabiciprilat
CAS No.	90103-92-7
Molecular Formula	C20H28N2O5
Molecular Weight	376.45 g/mol
Synonyms	(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid; Zabicipril Acid; Cilazaprilat Impurity; Zabicipril Metabolite; SQ 27,519; (S,S,S)-Zabiciprilat; ACE Inhibitor Metabolite
EINECS	Contact for details

Quality Control

Our Zabiciprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.