Description

(R)-Amlodipine Hemi-Dibenzoyl-L-Tartrate CAS NO 890046-37-4 is a high-purity, non-racemic salt form of the calcium channel blocker amlodipine, specifically engineered for advanced pharmaceutical research and development. This compound is a critical chiral intermediate for synthesizing enantiomerically pure (R)-amlodipine, which is essential for studying stereospecific drug activity and metabolism. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on cardiovascular drug discovery, process chemistry, and the development of novel single-enantiomer therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure (R)-amlodipine besylate and other active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in HPLC and chiral separation techniques.
• Pharmacological Research: Enables studies into the distinct biological activity, pharmacokinetics, and toxicity profile of the (R)-enantiomer separate from the (S)-enantiomer.
• Process Development & Optimization: Employed in scaling up and optimizing asymmetric synthesis routes for commercial production of chiral drugs.
• Impurity Profiling: Acts as a marker for identifying and quantifying enantiomeric impurities in amlodipine drug substances and finished dosage forms.
• Academic & Institutional Research: Supports fundamental research in medicinal chemistry, stereochemistry, and cardiovascular pharmacology.

Basic Information

Product Name	(R)-Amlodipine Hemi-Dibenzoyl-L-Tartrate
CAS No.	890046-37-4
Molecular Formula	C46H48ClN2O12
Molecular Weight	850.34 g/mol
Synonyms	(R)-Amlodipine Dibenzoyl-L-Tartrate Salt; (R)-Amlodipine Hemi-Dibenzoyltartrate; (R)-Amlodipine Hemi-(2R,3R)-Dibenzoyltartrate; (R)-Amlodipine Hemi-(+)-Dibenzoyl-L-Tartrate; Amlodipine Impurity R (as tartrate salt); (R)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hemi-dibenzoyl-L-tartrate; (R)-Amlodipine Hemi-DBT
EINECS	Contact for details

Quality Control

Our (R)-Amlodipine Hemi-Dibenzoyl-L-Tartrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.