Description

Azilsartan Kamedoxomil is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critically important for the synthesis of modern antihypertensive medications, offering a key building block for advanced cardiovascular therapies. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of sartan-class drugs.

Application

• Primary Pharmaceutical Ingredient: Key intermediate in the synthesis of Azilsartan medoxomil, a leading angiotensin II receptor blocker (ARB) for treating hypertension.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a critical precursor in large-scale GMP production of finished dosage forms (tablets).
• Research & Development: Used in pharmacological studies, metabolic pathway research, and the development of new cardiovascular drug formulations.
• Process Chemistry & Optimization: Employed in scaling up synthetic routes and improving yield and purity for commercial manufacturing.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and HPLC/LC-MS method development in pharmaceutical labs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Azilsartan Kamedoxomil
CAS No.	863031-24-7
Molecular Formula	C₃₀H₂₄N₄O₈
Molecular Weight	568.54 g/mol
Synonyms	Azilsartan Kamedoxomil; Azilsartan Medoxomil Intermediate; 2-Ethoxy-1-[[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl ester; TAK-491 Intermediate; Edarbi Intermediate; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-[[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate
EINECS	Contact for details

Quality Control

Our Azilsartan Kamedoxomil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) are provided with every shipment, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.