Description

3,5-Pyridinedicarboxylic Acid, 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydro-6-Methyl-, 3-Ethyl 5-Methyl Ester, (4R)-, Benzenesulfonate (1:1) is a high-purity, non-racemic pharmaceutical intermediate and active ingredient. This compound is critical for its role in the synthesis of advanced therapeutic agents, particularly in the cardiovascular and metabolic disease research sectors. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers of active pharmaceutical ingredients (APIs) for the production of novel, chirally pure drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel dihydropyridine-based calcium channel blockers and related therapeutic agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a direct precursor or the active moiety in the development of new chemical entities (NCEs) for cardiovascular diseases.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing for clinical trial material supply.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Biochemical Research: Utilized in pharmacological studies to investigate ion channel modulation and structure-activity relationships (SAR).
• Custom Synthesis: A starting material for the preparation of more complex, targeted analogs and derivatives for specialized research programs.

Basic Information

Item	Details
Product Name	3,5-Pyridinedicarboxylic Acid, 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydro-6-Methyl-, 3-Ethyl 5-Methyl Ester, (4R)-, Benzenesulfonate (1:1)
CAS No.	828247-64-9
Molecular Formula	C24H29ClN2O6 • C6H6O3S
Molecular Weight	Contact for details
Synonyms	(4R)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate; (R)-Amlodipine Besylate Intermediate; Amlodipine Besylate Related Compound R; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-(4R)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate; (R)-Amlodipine Benzenesulfonate; CAS 828247-64-9; (R)-Amlodipine Besylate
EINECS	Contact for details

Quality Control

Our 3,5-Pyridinedicarboxylic Acid, 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydro-6-Methyl-, 3-Ethyl 5-Methyl Ester, (4R)-, Benzenesulfonate (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided and can be tailored to meet specific client or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (4R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.