Description

Benazeprilat is the active metabolite of the widely prescribed antihypertensive drug benazepril, representing a key intermediate and reference standard in pharmaceutical research and development. Its primary commercial value lies in its critical role for analytical method development, quality control, and the synthesis of novel active pharmaceutical ingredients (APIs). This high-purity compound is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on cardiovascular drug development and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of benazepril and related drug products via HPLC, LC-MS, and other analytical techniques.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic building block in the production of benazepril and potentially other angiotensin-converting enzyme (ACE) inhibitors.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, bioavailability, and biological activity of benazepril in preclinical and clinical settings.
• Analytical Method Development: Critical for developing and validating robust quality control methods to ensure the safety and efficacy of final drug formulations.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing authenticated material for stability studies, impurity qualification, and method validation reports.
• Research Chemical: Used in biochemical and pharmacological research to investigate the mechanisms of ACE inhibition and cardiovascular physiology.

Basic Information

Product Name	Benazeprilat
CAS No.	89747-91-1
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	Benazeprilat; (3S)-3-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid; Benazepril Diacid; Benazeprilate; CGS 14831; CGS-14831; CGS14831; 1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-; Benazepril Impurity C
EINECS	Contact for details

Quality Control

Our Benazeprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities, to ensure it meets stringent standards suitable for pharmaceutical R&D and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.