Description

Imidaprilat is the active metabolite of the prodrug Imidapril, functioning as a potent and selective angiotensin-converting enzyme (ACE) inhibitor. This compound is of critical importance in pharmaceutical research and development for the creation of next-generation cardiovascular therapeutics. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on hypertension, heart failure, and renal disease research.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the commercial manufacturing of Imidapril and related antihypertensive drugs.
• Pharmacological Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of finished drug products.
• Biochemical Research: Employed in in vitro and ex vivo studies to investigate the mechanism of action of ACE inhibitors and their effects on the renin-angiotensin system.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism, distribution, and efficacy of Imidapril.
• Formulation Development: Used in pre-formulation and stability studies for developing new dosage forms.

Basic Information

Product Name	Imidaprilat
CAS No.	89371-44-8
Molecular Formula	C20H26N2O5
Molecular Weight	374.43 g/mol
Synonyms	(4S)-3-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid; (S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl-N-(3S)-1-methyl-2-oxo-3-imidazolidinylcarbonyl-L-proline; Imidapril Diacid; Imidaprilate; TA-6366
EINECS	Contact for details

Quality Control

Our Imidaprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.