Description

Dehydronitrendipine is a key pharmaceutical intermediate and a derivative of the dihydropyridine class of calcium channel blockers. This compound is essential for research and development in cardiovascular pharmacology, serving as a critical precursor for synthesizing active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of nitrendipine and related dihydropyridine calcium antagonists.
• Cardiovascular Research: Used in preclinical studies to investigate the structure-activity relationships (SAR) of calcium channel blockers.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for antihypertensive APIs.
• Chemical Synthesis: Used as a starting material or intermediate for creating novel dihydropyridine derivatives with potential therapeutic activity.

Basic Information

Product Name	Dehydronitrendipine
CAS No.	89267-41-4
Molecular Formula	C18H16N2O6
Molecular Weight	356.33 g/mol
Synonyms	Dehydronitrendipine; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester; Ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Dehydro form); Nitrendipine Impurity; Nitrendipine Related Compound
EINECS	Contact for details

Quality Control

Our Dehydronitrendipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.