Description

Manidipine Hydrochloride is a high-purity pharmaceutical active ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is a critical intermediate and active substance used in the development and manufacturing of antihypertensive medications. This compound is essential for pharmaceutical companies, research institutions, and fine chemical suppliers focused on cardiovascular drug development and generic API production.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of antihypertensive and antianginal medications.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Research & Development: Key compound in preclinical and clinical studies investigating calcium channel blockade and cardiovascular pharmacology.
• Generic Drug Manufacturing: Essential raw material for the production of generic versions of calcium channel blocker drugs containing manidipine.
• Biochemical Research: Used in studies of vascular smooth muscle contraction and ion channel function.

Basic Information

Item	Details
Product Name	Manidipine Hydrochloride
CAS No.	89226-75-5
Molecular Formula	C35H38N4O6 • HCl
Molecular Weight	647.16 g/mol
Synonyms	Manidipine HCl; (±)-Manidipine Hydrochloride; 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride; CAS 89226-75-5; Frandipine; Calslot; Manyper; CV-4093 hydrochloride
EINECS	Contact for details

Quality Control

Our Manidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We can support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.