Description

Manidipine is a potent and selective calcium channel blocker belonging to the dihydropyridine class, primarily used as an active pharmaceutical ingredient (API). Its high selectivity for vascular smooth muscle makes it a critical component in the development of antihypertensive medications, offering effective blood pressure control. This compound is essential for pharmaceutical manufacturers and research institutions focused on cardiovascular drug development, formulation, and analytical reference standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive tablet formulations.
• Cardiovascular Research: A key reference compound in pharmacological studies of calcium channel modulation and vascular tone.
• Analytical Standard: Serves as a high-purity reference standard for HPLC, LC-MS, and other analytical method development and validation.
• Formulation Development: Used in R&D for developing new drug delivery systems, including controlled-release and combination therapies.
• Generic Drug Manufacturing: A critical raw material for the production of generic versions of manidipine-based medications.
• Biochemical Studies: Utilized in vitro and in vivo studies to investigate its mechanism of action and metabolic pathways.

Basic Information

Product Name	Manidipine
CAS No.	89226-50-6
Molecular Formula	C35H38N4O6
Molecular Weight	610.70 g/mol
Synonyms	Manidipine Hydrochloride; Manidipine HCl; (±)-Manidipine; CV-4093; Calslot; Manyper; Franidipine; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester; 2-[4-(Benzhydryl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our Manidipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and detailed Certificates of Analysis (COA) upon request, confirming compliance with in-house specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.