Description

Fosinopril Sodium is the sodium salt of fosinopril, an angiotensin-converting enzyme (ACE) inhibitor. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of cardiovascular medications. It is primarily used by pharmaceutical manufacturers in the production of antihypertensive and heart failure drugs. Global supply chains rely on consistent quality and reliable documentation for this essential compound, CAS NO 88889-14-9.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension (high blood pressure).
• Cardiovascular Drug Formulation: Essential component in the manufacture of tablets and other oral medications for managing congestive heart failure.
• Generic Drug Production: Sourcing for manufacturers producing bioequivalent generic versions of brand-name ACE inhibitor medications.
• Clinical Research: Used as a reference standard or raw material in preclinical and clinical studies for new cardiovascular therapies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for production under cGMP guidelines.

Basic Information

Product Name	Fosinopril Sodium
CAS No.	88889-14-9
Molecular Formula	C30H45NNaO7P
Molecular Weight	585.65 g/mol
Synonyms	Fosinopril Sodium Salt; SQ 28,555; SQ-28555; (4S)-4-Cyclohexyl-1-[[(R)-[[(1S)-1-carboxy-3-phenylpropyl]amino](phenylphosphinyl)acetyl]oxy]-L-proline Sodium Salt; Monopril (brand name variant); Fosinoprilat Ester Sodium Salt; L-Proline, 4-cyclohexyl-1-[[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]oxy]-, sodium salt, (4S)-; Phosphinic acid, [[1-(carboxy-3-phenylpropyl)-L-prolyl]oxy]-, sodium salt, P-phenyl
EINECS	Contact for details

Quality Control

Our Fosinopril Sodium is manufactured and tested to meet the highest pharmacopeial standards, including USP and EP monographs. Each batch undergoes rigorous analytical testing for identity, purity, and impurity profiles using advanced techniques like HPLC. A comprehensive Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.2%
Specific Rotation	-14.0° to -18.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.