Description

Cilazapril CAS NO 88768-40-5 is a potent and selective angiotensin-converting enzyme (ACE) inhibitor, widely recognized as a key pharmaceutical intermediate and active pharmaceutical ingredient (API). Its primary value lies in its critical role in the synthesis of antihypertensive and cardiovascular medications, offering high biological activity and specificity. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing advanced treatments for hypertension and heart failure.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the manufacture of antihypertensive drugs.
• Cardiovascular Drug Formulation: Key component in medications for treating hypertension, congestive heart failure, and post-myocardial infarction.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of the renin-angiotensin system.
• Generic Drug Production: Serves as a critical building block for manufacturers of generic versions of ACE inhibitor medications.
• Preclinical & Clinical Development: Employed in the R&D phases for new cardiovascular therapeutic agents.

Basic Information

Product Name	Cilazapril
CAS No.	88768-40-5
Molecular Formula	C22H31N3O5
Molecular Weight	417.50 g/mol
Synonyms	Cilazapril; (S)-1-[(S)-6-cyclohexyl-1-oxo-1,6-hexanediyl]oxy]-2-oxo-1-ethyl-L-proline; Ro 31-2848; Inhibace; Vascace; Dynorm; 1H-Pyrrole-1-hexanoic acid, 2-(1-ethoxy-1-oxo-4-phenylbutyl)-4,5-dihydro-7-methyl-, ethyl ester, (2S,4S)-; (4S,7S)-7-[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyrido[1,2-a][1,2]diazepine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our Cilazapril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing parameters such as assay, related substances, and residual solvents. We support compliance with ICH guidelines and relevant pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (Karl Fischer)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.