Description

Trandolaprilat is the active diacid metabolite of the prodrug trandolapril, functioning as a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor. This high-purity active pharmaceutical ingredient (API) is critical for the research, development, and manufacturing of cardiovascular therapeutics. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and advanced chemical synthesis laboratories focused on hypertension and heart failure treatments. The compound, identified as CAS NO 87679-71-8, is supplied under stringent quality controls to ensure reliability for critical applications.

Application

• Pharmaceutical API Synthesis: Primary active ingredient for the manufacture of trandolapril-based antihypertensive and heart failure medications.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical labs.
• Biomedical Research: Used in preclinical and clinical studies to investigate the mechanisms of ACE inhibition and cardiovascular pharmacology.
• Metabolite Studies: Essential for pharmacokinetic and metabolic profiling studies related to trandolapril.
• Process Development: Key intermediate in the research and scale-up of novel synthetic routes for ACE inhibitor drugs.
• Formulation Development: Employed in the development of stable and bioavailable dosage forms.

Basic Information

Product Name	Trandolaprilat
CAS No.	87679-71-8
Molecular Formula	C24H34N2O5
Molecular Weight	430.54 g/mol
Synonyms	(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; Trandolapril Diacid; RU 44403; RU-44403; Odrik Metabolite; Gopten Metabolite
EINECS	Contact for details

Quality Control

Our Trandolaprilat is manufactured and tested to meet exacting standards suitable for pharmaceutical research and development. Quality is assured through a comprehensive battery of analytical tests including HPLC, NMR, and mass spectrometry for identity and purity confirmation. We adhere to cGMP principles where applicable, and a detailed Certificate of Analysis (COA) is provided with each batch to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.