Description

Ramipril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor widely recognized for its cardiovascular therapeutic benefits. This active pharmaceutical ingredient (API) is critical for the formulation of medications used to manage hypertension and congestive heart failure, and to improve survival following a myocardial infarction. It is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular drugs, requiring a reliable supply of high-purity material to ensure final product efficacy and safety.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and cardioprotective medications.
• Tablet Formulation: Used in the manufacture of solid oral dosage forms, including immediate-release and combination tablets.
• Capsule Production: Incorporated into hard gelatin or softgel capsules for oral administration.
• Cardiovascular Research: Serves as a key reference standard and investigational compound in preclinical and clinical studies for heart disease.
• Generic Drug Manufacturing: A vital component for companies producing bioequivalent generic versions of branded ramipril drugs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific drug production.

Basic Information

Product Name	Ramipril
CAS No.	87333-19-5
Molecular Formula	C23H32N2O5
Molecular Weight	416.51 g/mol
Synonyms	(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid; Altace; Triatec; Cardace; Ramace; Tritace; Ramiprilum; Ramipril API
EINECS	Contact for details

Quality Control

Our Ramipril is manufactured under strict quality management systems, with specifications designed to meet or exceed major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.