Description

Ramiprilat is the active diacid metabolite of the widely prescribed antihypertensive drug Ramipril. This compound is a critical pharmaceutical intermediate and reference standard in the research, development, and quality control of angiotensin-converting enzyme (ACE) inhibitors. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on cardiovascular therapeutics, metabolism studies, and impurity profiling.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: A key metabolite and synthetic precursor in the production of Ramipril and related cardiovascular drugs.
• Analytical Reference Standard: Used for identification, assay, and impurity quantification in pharmaceutical quality control (QC) and quality assurance (QA) laboratories.
• Metabolite Research: Critical for pharmacokinetic and pharmacodynamic studies to understand the metabolism, efficacy, and safety profile of Ramipril.
• Impurity Standard: Serves as a certified reference material for monitoring and controlling process-related impurities and degradation products in finished dosage forms.
• Biochemical Research: Used in enzymatic studies as a potent inhibitor to investigate the mechanism of action of ACE and related enzymes.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing authentic material for method validation and stability studies.

Basic Information

Product Name	Ramiprilat
CAS No.	87269-97-4
Molecular Formula	C23H32N2O5
Molecular Weight	416.51 g/mol
Synonyms	(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid; Ramipril Diacid; Ramiprilate; Hoe 498 Diacid; Triate; Trandolaprilat Impurity; ACE Inhibitor Metabolite
EINECS	Contact for details

Quality Control

Our Ramiprilat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral chromatography for enantiomeric purity, and comprehensive identification tests to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.