Description

Benazeprilat is the active metabolite of the widely prescribed antihypertensive drug, Benazepril. This high-purity pharmaceutical intermediate is critical for research, analytical standard preparation, and the development of new cardiovascular therapies. It is primarily utilized by pharmaceutical manufacturers, research institutions, and quality control laboratories engaged in drug development, metabolism studies, and regulatory compliance testing for angiotensin-converting enzyme (ACE) inhibitors.

Application

• Pharmaceutical Intermediate: Serves as the key active metabolite in the synthesis and development of Benazepril and related prodrugs.
• Analytical Reference Standard: Used in high-performance liquid chromatography (HPLC), mass spectrometry (MS), and other analytical methods for quantitative and qualitative analysis.
• Metabolism and Pharmacokinetic Studies: Essential for in vitro and in vivo research to understand the biotransformation, distribution, and efficacy of ACE inhibitor drugs.
• Quality Control & Assurance: Employed by pharmaceutical QC labs to verify the identity, purity, and potency of drug substances and finished products.
• Biochemical Research: Used as a tool compound in studies investigating the renin-angiotensin system and its role in cardiovascular physiology and disease.
• Impurity Profiling: Critical for identifying and quantifying related substances and degradation products in pharmaceutical formulations to ensure safety and compliance.

Basic Information

Product Name	Benazeprilat
CAS No.	86541-78-8
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	Benazeprilat; (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid; Benazepril diacid; CGS 14831; CGS-14831; CGS14831; Benazeprilic acid; Benazepril metabolite
EINECS	Contact for details

Quality Control

Our Benazeprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.