Description

(1R,3S)-Benazepril Hydrochloride is a high-purity, single-enantiomer active pharmaceutical ingredient (API) and a key intermediate in the synthesis of the ACE inhibitor benazepril. This specific stereoisomer is critical for ensuring the intended pharmacological activity and therapeutic efficacy of the final drug product. It is essential for pharmaceutical manufacturers and advanced research institutions engaged in the development and production of cardiovascular medications, analytical reference standards, and novel chemical entities.

Application

• Pharmaceutical API Synthesis: Primary use as a key chiral building block in the commercial manufacturing of the antihypertensive drug Benazepril.
• Research & Development: Serves as a critical intermediate in medicinal chemistry programs for developing new ACE inhibitors or related cardiovascular agents.
• Analytical Reference Standard: Used in quality control laboratories for HPLC, LC-MS, or NMR method development and validation to ensure drug purity and identity.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for benazepril in pilot plants and production facilities.
• Academic Research: Utilized in university and institutional studies focusing on stereochemistry, enzyme inhibition, and pharmacokinetics.

Basic Information

Product Name	(1R,3S)-Benazepril Hydrochloride
CAS No.	86541-77-7
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol
Synonyms	Benazepril Hydrochloride (1R,3S)-isomer; (3S)-3-[[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; (S)-Benazepril Hydrochloride; CGS-14824A; CGS 14824A; (1R,3S)-1-(Carboxymethyl)-3-[[(1R)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one hydrochloride; Benazeprilat Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our (1R,3S)-Benazepril Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.