Description

Benazepril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used primarily as an active pharmaceutical ingredient (API). It is a critical compound for the development and manufacturing of antihypertensive and heart failure medications, offering effective blood pressure control and cardiovascular protection. This high-purity intermediate is essential for pharmaceutical companies, research institutions, and contract manufacturing organizations (CMOs) engaged in the production of finished dosage forms.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive tablet and capsule formulations.
• Cardiovascular Drug Synthesis: Key intermediate in the synthesis of medications for treating hypertension, congestive heart failure, and diabetic nephropathy.
• Research & Development: Used in preclinical and clinical studies for investigating new cardiovascular therapies and combination drugs.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of ACE inhibitor medications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.

Basic Information

Product Name	Benazepril
CAS No.	86541-75-5
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol (Hydrochloride salt)
Synonyms	Benazepril Hydrochloride; CGS-14824A; CGS 14824; (3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; Benzazepril; Lotensin (brand name API)
EINECS	Contact for details

Quality Control

Our Benazepril is manufactured under strict quality management systems. It is typically supplied to meet pharmaceutical-grade specifications, with testing aligned to major pharmacopoeial standards such as USP and EP. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.