Description

Benazepril Hydrochloride is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used as an active pharmaceutical ingredient (API). It is critical for the formulation of antihypertensive and heart failure medications, offering effective blood pressure control and cardiovascular protection. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in producing generic and branded cardiovascular therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive tablet and capsule formulations.
• Cardiovascular Drug Manufacturing: Core component for drugs treating hypertension, congestive heart failure, and diabetic nephropathy.
• Generic Drug Development: Serves as a key reference standard and bulk material for generic pharmaceutical companies.
• Clinical Research: Used in preclinical and clinical studies for developing new cardiovascular treatment regimens.
• Veterinary Medicine: Applied in formulations for managing hypertension in companion animals.
• Reference Standard: Utilized in quality control laboratories for HPLC/UV assay calibration and method validation.

Basic Information

Product Name	Benazepril Hydrochloride
CAS No.	86541-74-4
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol
Synonyms	Benazepril HCl; CGS-14824A; CGS 14824A; (3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; Benzazepril Hydrochloride; Lotensin (brand name API)
EINECS	Contact for details

Quality Control

Our Benazepril Hydrochloride is manufactured under cGMP conditions and undergoes rigorous analytical testing to ensure it meets stringent pharmacopeial standards. Quality is verified against specifications from USP, EP, and ICH guidelines, covering identity, purity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF Titration)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%
Microbiological Enumeration	Complies with EP/USP for non-sterile APIs

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.