Description

Benazepril Hydrochloride is a potent and selective angiotensin-converting enzyme (ACE) inhibitor, widely recognized for its critical role in cardiovascular therapy. Its primary value lies in providing reliable and consistent quality for the formulation of finished pharmaceutical products, ensuring therapeutic efficacy and patient safety. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry producing antihypertensive and heart failure medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of hypertension (high blood pressure).
• Cardiovascular Formulations: Incorporated into tablets and capsules for managing heart failure and improving survival after myocardial infarction.
• Combination Drug Therapy: Used in fixed-dose combination products with other antihypertensive agents like calcium channel blockers or diuretics.
• Clinical Research: Serves as a reference standard and raw material in preclinical and clinical studies for cardiovascular diseases.
• Generic Drug Manufacturing: A key component for pharmaceutical companies producing bioequivalent generic versions of brand-name ACE inhibitor drugs.

Basic Information

Product Name	Benazepril Hydrochloride
CAS No.	86499-20-9
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol
Synonyms	Benazepril HCl; (3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; CGS-14824A; CGS 14824; Lotensin (brand name active ingredient); Briem; Zinadril; Labaz; Gibacen
EINECS	Contact for details

Quality Control

Our Benazepril Hydrochloride is manufactured under strict quality management systems. We ensure compliance with major pharmacopoeial standards, including USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs, where applicable. Every batch undergoes rigorous analytical testing for identity, purity, potency, and impurity profiles. Certificates of Analysis (COA) documenting full compliance with specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Ensure the storage area is well-ventilated and away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	-140° to -150° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.