Description

3-Pyridinecarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl Ester is a high-purity, synthetically valuable dihydropyridine derivative. This compound serves as a critical advanced intermediate in the research and development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical synthesis companies for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of calcium channel blockers and other cardiovascular drug candidates.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its nitrophenyl and dihydropyridine motifs.
• Organic Synthesis: Serves as a versatile precursor for further functionalization, including reduction of the nitro group or hydrolysis of the ester.
• Chemical Research: Employed in academic and industrial research for studying structure-activity relationships (SAR) and heterocyclic chemistry.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	3-Pyridinecarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl Ester
CAS No.	85831-33-0
Molecular Formula	C16H16N2O4
Molecular Weight	300.31 g/mol
Synonyms	Methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylate; 3-Nifedipine; 4-(3-Nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl ester; Nifedipine Impurity F (EP); Nifedipine Related Compound F (USP); 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid methyl ester; 4-(3-Nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid 3-methyl ester
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl Ester is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.