Description

Quinaprilat is the active diacid metabolite of the ACE inhibitor quinapril. This high-purity pharmaceutical intermediate is critical for research and development in cardiovascular pharmacology. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing and analyzing antihypertensive agents and heart failure treatments. Our supply ensures the stringent quality and consistency required for advanced pharmaceutical applications.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as a key metabolite and reference standard in the development and quality control of quinapril and related prodrugs.
• Biomedical Research: Used as a critical tool in in vitro and in vivo studies to investigate the mechanisms of angiotensin-converting enzyme (ACE) inhibition.
• Analytical Reference Standard: Employed in HPLC, LC-MS, and other chromatographic methods for the quantitative and qualitative analysis of quinapril in biological matrices and pharmaceutical formulations.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism, bioavailability, and activity profile of quinapril.

Basic Information

Product Name	Quinaprilat
CAS No.	85441-60-7
Molecular Formula	C25H30N2O5
Molecular Weight	438.52 g/mol
Synonyms	(3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; Quinapril Diacid; CI-928; Quinaprilat (USAN); (S,S,S)-N-(1-Carboxy-3-phenylpropyl)alanyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our Quinaprilat is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing specific results for parameters such as assay (by HPLC), related substances, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.