Description

2,6-Dimethyl-3,5-Diethoxycarbonyl-4-(o-Difluoromethylsulfonylphenyl)-1,4-Dihydropyridine is a high-purity, advanced pharmaceutical intermediate belonging to the 1,4-dihydropyridine class. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for R&D laboratories and manufacturers in the pharmaceutical and fine chemical sectors requiring precise molecular scaffolds for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel 1,4-dihydropyridine-based calcium channel blockers and other therapeutic agents.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Fine Chemical Synthesis: Serves as a versatile building block for constructing complex heterocyclic compounds in custom synthesis projects.
• Academic Research: Employed in university and institutional labs for studying dihydropyridine chemistry and reaction mechanisms.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of high-value, low-volume specialty APIs.

Basic Information

Product Name	2,6-Dimethyl-3,5-Diethoxycarbonyl-4-(o-Difluoromethylsulfonylphenyl)-1,4-Dihydropyridine
CAS No.	84761-75-1
Molecular Formula	C20H23F2NO6S
Molecular Weight	443.46 g/mol
Synonyms	4-(2-(Difluoromethylsulfonyl)phenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine; 3,5-Diethyl 2,6-dimethyl-4-[2-[(difluoromethyl)sulfonyl]phenyl]-1,4-dihydro-3,5-pyridinedicarboxylate; 1,4-DHP Derivative; Difluoromethylsulfonyl DHP Ester; o-Difluoromethylsulfonylphenyl DHP; CAS 84761-75-1
EINECS	Contact for details

Quality Control

Our 2,6-Dimethyl-3,5-Diethoxycarbonyl-4-(o-Difluoromethylsulfonylphenyl)-1,4-Dihydropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.