Description

Enalaprilat Dihydrate is the active diacid metabolite of the prodrug enalapril, functioning as a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). This compound is critical for the development and quality control of cardiovascular pharmaceuticals, particularly antihypertensive agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the synthesis of ACE inhibitors, analytical method development, and reference standard preparation.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacturing of enalapril maleate and related prodrug formulations.
• Pharmaceutical Reference Standard: Used for identity confirmation, assay calibration, and impurity profiling in quality control laboratories to ensure drug product consistency.
• Biochemical Research: Employed in pharmacological and pharmacokinetic studies to investigate the mechanism of action, metabolism, and structure-activity relationships of ACE inhibitors.
• Analytical Method Development: Serves as a critical standard for developing and validating HPLC, LC-MS, and other chromatographic methods for potency and purity testing.
• Formulation Development: Used in pre-formulation studies for stability testing and compatibility assessments in solid and liquid dosage forms.

Basic Information

Product Name	Enalaprilat Dihydrate
CAS No.	84680-54-6
Molecular Formula	C18H24N2O5 · 2H2O
Molecular Weight	384.42 g/mol
Synonyms	Enalaprilat Dihydrate; (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline Dihydrate; MK-422 Dihydrate; Vasotec Impurity; Enalapril Diacid Dihydrate; Enalaprilat (Dihydrate); N-[(S)-1-Carboxy-3-phenylpropyl]-L-Ala-L-Pro Dihydrate
EINECS	Contact for details

Quality Control

Our Enalaprilat Dihydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical development and research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, purity (by HPLC), water content, residue on ignition, and related substances. We support compliance with ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	8.0% - 10.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.