Description

(±)-Diltiazem CAS NO 84675-89-8 is a calcium channel blocker of the benzothiazepine class, serving as a key pharmaceutical intermediate and reference standard. Its primary commercial value lies in its critical role in the research, development, and quality control of cardiovascular medications. This compound is essential for pharmaceutical manufacturers, analytical laboratories, and R&D facilities focused on producing or verifying the quality of diltiazem-based active pharmaceutical ingredients (APIs) and finished dosage forms.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of the active pharmaceutical ingredient (API) Diltiazem Hydrochloride.
• Reference Standard: Serves as a critical standard for identity, assay, and impurity testing in pharmaceutical quality control (QC) and quality assurance (QA) laboratories.
• Research & Development: Used in preclinical and clinical research for studying calcium channel blockade, pharmacokinetics, and metabolite profiling.
• Analytical Method Development: Employed for developing and validating HPLC, GC, and other chromatographic methods for diltiazem analysis.
• Impurity Standard: Utilized as a marker for related substance testing and stability studies of diltiazem formulations.
• Chemical Synthesis: Acts as a building block for the preparation of novel diltiazem analogs and derivatives in medicinal chemistry.

Basic Information

Product Name	(±)-Diltiazem
CAS No.	84675-89-8
Molecular Formula	C22H26N2O4S
Molecular Weight	414.52 g/mol
Synonyms	Diltiazem Base; Diltiazem Free Base; D-cis-Diltiazem; (+)-cis-Diltiazem; (2S,3S)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-4-methyl-1,5-benzothiazepin-4(5H)-one; (±)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; Benzothiazepin-4(5H)-one derivative; Cardizem Intermediate
EINECS	Contact for details

Quality Control

Our (±)-Diltiazem is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and related substance analysis, to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.