Description

Spirapril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used in the management of hypertension and heart failure. Its primary value lies in its ability to effectively lower blood pressure and reduce cardiac workload, offering a critical therapeutic option for cardiovascular disease management. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing finished dosage forms, such as tablets and capsules, for the global healthcare market.

Application

• Primary Active Pharmaceutical Ingredient (API) in antihypertensive medications.
• Key component in the formulation of combination therapies for cardiovascular diseases.
• Used in clinical research and development of new cardiovascular drug formulations.
• Reference standard for analytical testing and quality control in pharmaceutical laboratories.
• Raw material for the production of generic spirapril-based pharmaceutical products.

Basic Information

Item	Details
Product Name	Spirapril
CAS No.	83647-97-6
Molecular Formula	C22H30N2O5S2
Molecular Weight	466.62 g/mol
Synonyms	Spirapril; (8S)-7-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid; SCH 33844; Renormax; Sandopril; Quadropril; Spirapril hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Spirapril is manufactured under strict quality systems to ensure it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via validated methods such as HPLC. A Certificate of Analysis (COA) documenting compliance with relevant specifications is provided with every shipment to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.