Description

Spiraprilat is the active diacid metabolite of the prodrug ACE inhibitor Spirapril. This high-purity pharmaceutical intermediate is critical for research and development in cardiovascular pharmacology, particularly in studies related to angiotensin-converting enzyme (ACE) inhibition. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on developing or quality-controlling antihypertensive and heart failure medications. Spiraprilat CAS NO 83602-05-5 offers a reliable reference standard for method development and validation.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative and qualitative analysis of Spirapril and its metabolites in drug substances and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor or metabolite in the development and manufacturing of Spirapril-based cardiovascular drugs.
• Biomedical Research: Used in in vitro and in vivo studies to investigate the mechanisms of ACE inhibition, pharmacokinetics, and pharmacodynamics.
• Analytical Method Development: Critical for developing and validating HPLC, LC-MS, and other chromatographic assays in quality control laboratories.
• Metabolite Studies: Employed in clinical and pre-clinical research to understand the metabolic pathway and bioavailability of Spirapril.
• Impurity Profiling: Used to identify and quantify related substances and degradation products in pharmaceutical formulations to ensure safety and efficacy.

Basic Information

Product Name	Spiraprilat
CAS No.	83602-05-5
Molecular Formula	C22H30N2O5S2
Molecular Weight	466.61 g/mol
Synonyms	Spirapril diacid; (S)-1-[(S)-2-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-1-oxopropyl]octahydro-2H-indole-2-carboxylic acid; SC-46944; Spirapril metabolite; 1-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-2-indolecarboxylic acid 1-ethyl ester hydrolysis product
EINECS	Contact for details

Quality Control

Our Spiraprilat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.