Description

Trandolaprilat is the active diacid metabolite of the prodrug trandolapril, representing a key intermediate and reference standard in pharmaceutical research and development. This compound is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor, crucial for the study of cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and analytical service providers focused on hypertension and heart failure treatments. The material is supplied to meet the stringent quality requirements of the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: A critical metabolite and synthetic precursor in the production of trandolapril and related cardiovascular drugs.
• Reference Standard for Analytical Testing: Used in HPLC, LC-MS, and other chromatographic methods for method development, validation, and quality control of drug substances and products.
• Biochemical Research: Employed in pharmacological and pharmacokinetic studies to investigate ACE inhibition mechanisms, metabolic pathways, and drug-receptor interactions.
• Impurity Standard: Serves as a certified reference material for identifying and quantifying related substances and degradation products in trandolapril formulations.
• Process Development & Scale-up: Used in optimizing synthetic routes and purification processes during the development of ACE inhibitor therapeutics.

Basic Information

Product Name	Trandolaprilat
CAS No.	83601-86-9
Molecular Formula	C24H34N2O5
Molecular Weight	430.54 g/mol
Synonyms	(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; Trandolapril Diacid; RU 44403; RU-44403; Trandolaprilat (USAN); Trandolapril Metabolite; (S,S,S)-Trandolaprilat
EINECS	Contact for details

Quality Control

Our Trandolaprilat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We can supply material that meets in-house specifications and support development toward recognized pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual unknown impurity: ≤0.5% Total impurities: ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.