Description

Spiraprilat is the active diacid metabolite of the angiotensin-converting enzyme (ACE) inhibitor Spirapril. This compound is a critical intermediate and reference standard in the research, development, and quality control of cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for the production and validation of antihypertensive medications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of Spirapril and related drug products in compliance with pharmacopeial methods (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the manufacturing process of Spirapril hydrochloride and other ACE inhibitor APIs.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the metabolism, efficacy, and safety profile of Spirapril.
• Analytical Method Development: Employed in the development and validation of high-performance liquid chromatography (HPLC), LC-MS, and other analytical techniques for cardiovascular drugs.
• Quality Control & Assurance: Critical for routine batch testing in pharmaceutical quality control laboratories to ensure product purity, potency, and consistency.
• Biochemical Research: Used as a tool compound in biochemical assays to study the mechanism of action of ACE inhibition and its role in the renin-angiotensin system.

Basic Information

Product Name	Spiraprilat
CAS No.	83507-88-4
Molecular Formula	C22H30N2O5S2
Molecular Weight	466.61 g/mol
Synonyms	Spirapril Diacid; (S)-1-[(S)-2-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; SCH 33844 Diacid; Spiraprilate; Spirapril Metabolite; Spirapril Acid; 1H-Indole-2-carboxylic acid, octahydro-α-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-, (αS,1S,2S)-; Spirapril-diacid
EINECS	Contact for details

Quality Control

Our Spiraprilat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.