Description

Quinaprilat Hydrate CAS NO 82768-85-2 is the active diacid metabolite of the angiotensin-converting enzyme (ACE) inhibitor quinapril. This compound is of significant interest in pharmaceutical research and development, serving as a critical reference standard and a key intermediate. It is primarily utilized by research institutions and pharmaceutical manufacturers involved in cardiovascular drug development, analytical method validation, and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and purity testing of quinapril and its related products in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic precursor in the manufacturing process of quinapril hydrochloride.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the metabolism and efficacy of quinapril.
• Analytical Method Development: Employed as a benchmark compound for developing and validating HPLC, LC-MS, and other chromatographic methods.
• Biochemical Research: Used in studies targeting the ACE enzyme mechanism and for screening novel cardiovascular agents.
• Impurity Profiling: Acts as a specified impurity standard to monitor and control the quality of quinapril drug substances and finished dosage forms.

Basic Information

Product Name	Quinaprilat Hydrate
CAS No.	82768-85-2
Molecular Formula	C25H30N2O5 • xH2O
Molecular Weight	438.52 (Anhydrous basis)
Synonyms	(3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrate; Quinaprilat monohydrate; Quinapril diacid; CI-928; Accupril metabolite; (S,S,S)-N-(1-Carboxy-3-phenylpropyl)-Ala-Pro diacid hydrate
EINECS	Contact for details

Quality Control

Our Quinaprilat Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. We provide full traceability and Certificates of Analysis (COA) detailing identity, purity (by HPLC), water content, and related substances. Specifications can be aligned with pharmacopeial guidelines (e.g., USP reference standards) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.