Description

Moexiprilat Hydrate is the active metabolite of the ACE inhibitor Moexipril, representing a key pharmaceutical intermediate and reference standard. Its primary value lies in its role in cardiovascular research and the development and quality control of antihypertensive medications. This compound is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on metabolic studies, drug impurity profiling, and the synthesis of advanced therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for drug quantification and impurity analysis.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical precursor in the synthesis of Moexipril and related cardiovascular drugs.
• Metabolic and Pharmacokinetic Research: Employed in studies to understand the biotransformation, distribution, and efficacy of ACE inhibitor therapies.
• Quality Control & Assurance: Serves as a system suitability standard in pharmaceutical manufacturing to ensure batch consistency and regulatory compliance.
• Biochemical Research: Used in enzymatic assays to study angiotensin-converting enzyme (ACE) inhibition mechanisms.
• Impurity Standard: Critical for identifying and quantifying related substances in Moexipril drug substance and finished dosage forms.

Basic Information

Product Name	Moexiprilat Hydrate
CAS No.	82586-57-0
Molecular Formula	C27H34N2O7 • xH2O
Molecular Weight	498.57 g/mol (anhydrous basis)
Synonyms	Moexiprilat; Moexipril Acid; (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic Acid Hydrate; Moexipril Diacid; Moexiprilat Monohydrate; RS-10085; UNII-9E5N90G8AJ
EINECS	Contact for details

Quality Control

Our Moexiprilat Hydrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and HPLC, assay determination, and control of specified impurities and residual solvents to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.