Description

Quinapril Hydrochloride CAS NO 82586-55-8 is a high-purity active pharmaceutical ingredient (API) belonging to the angiotensin-converting enzyme (ACE) inhibitor class. It is a critical component in the formulation of antihypertensive and heart failure medications, valued for its efficacy and reliability. This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug development and production.

Application

• Primary Pharmaceutical Ingredient: Core API in the manufacture of finished dosage forms for hypertension management.
• Cardiovascular Drug Formulations: Used in tablets and capsules for the treatment of congestive heart failure.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological studies and new drug development.
• Generic Drug Manufacturing: A vital component for companies producing bioequivalent generic versions of ACE inhibitor medications.
• Clinical Trial Material: Supplied as GMP-grade material for use in Phase I-III clinical studies.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC and other analytical methods.

Basic Information

Product Name	Quinapril Hydrochloride
CAS No.	82586-55-8
Molecular Formula	C25H30N2O5·HCl
Molecular Weight	474.98 g/mol
Synonyms	Quinapril HCl; (S)-3-[(S)-2-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride; CI-906; Accupril (brand name API); Quinaprilum Hydrochloridum; Quinapril Hydrochloride (USP); Quinapril Monohydrochloride
EINECS	Contact for details

Quality Control

Our Quinapril Hydrochloride is manufactured under strict quality management systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including identity, purity, and impurity profile determination. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Optical Rotation	-15.0° to -18.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.