Description

1-[n-[1-(Ethoxycarbonyl)-3-Phenylpropyl]-L-Alanyl]-L-Proline Maleate is a high-purity, non-peptide angiotensin-converting enzyme (ACE) inhibitor intermediate. This compound is critical for ensuring the efficacy and consistency of final active pharmaceutical ingredients (APIs) in cardiovascular therapeutics. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of antihypertensive and heart failure medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced ACE inhibitor APIs.
• Cardiovascular Drug Research: Used in preclinical and clinical research for developing new antihypertensive agents.
• Process Development: Serves as a reference standard for optimizing synthetic routes and scaling up production.
• Quality Control Standard: Employed as an analytical reference standard in HPLC and other chromatographic methods for impurity profiling and assay validation.
• Academic & Contract Research: Utilized in biochemical studies to investigate the mechanism of ACE inhibition.

Basic Information

Product Name	1-[n-[1-(Ethoxycarbonyl)-3-Phenylpropyl]-L-Alanyl]-L-Proline Maleate
CAS No.	82009-37-8
Molecular Formula	C23H30N2O6 • C4H4O4
Molecular Weight	522.55 g/mol
Synonyms	Lisinopril Maleate Intermediate; (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline Maleate Salt; Lisinopril Related Compound; 1-[N2-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-lysyl]-L-proline Maleate; ACE Inhibitor Intermediate; Zestril Intermediate; Prinivil Intermediate; MK-521 Maleate
EINECS	Contact for details

Quality Control

Our 1-[n-[1-(Ethoxycarbonyl)-3-Phenylpropyl]-L-Alanyl]-L-Proline Maleate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.